It's so frustrating for your contacts to unsubscribe from your list, only to get another email the following day or week. They don't understand that you have multiple lists and they only removed themselves from *one* list, not all of them. In their frustration they mark your next message as spam, which negatively affects your deliverability. No bueno.
This automation triggers on contact unsubscribe and removes the contact from all lists, with the added option of removing the individual automations as well (which you can customize). It leaves all tags in tact, and adds another tag called "unsubscribed from all lists" so you can easily track and report on contacts who trigger the automation.